There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to reduce afferent suffering transmission and make analgesia. Hence, medicines like clonidine that focus on alpha-two receptors can affect the transmission of soreness. Clonidine is dispersed in breast milk; https://bookmarkpath.com/story19698720/the-basic-principles-of-onolidine